Alexander Stark

Principles of MicroRNA–Target Recognition

MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression in plants and animals. Although their biological importance has become clear, how they recognize and r...

Reliable prediction of regulator targets using 12 <i>Drosophila</i> genomes

Gene expression is regulated pre- and post-transcriptionally via cis -regulatory DNA and RNA motifs. Identification of individual functional instances of such motifs in genome s...

Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR Evolution

Evolution, biogenesis, expression, and target predictions of a substantially expanded set of <i>Drosophila</i> microRNAs

MicroRNA (miRNA) genes give rise to small regulatory RNAs in a wide variety of organisms. We used computational methods to predict miRNAs conserved among Drosophila species and ...

Systematic discovery and characterization of fly microRNAs using 12 <i>Drosophila</i> genomes

MicroRNAs (miRNAs) are short regulatory RNAs that inhibit target genes by complementary binding in 3′ untranslated regions (3′ UTRs). They are one of the most abundant classes o...