Andrew E. Jaffe

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders, including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD), lags be...

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

Comprehensive functional genomic resource and integrative model for the human brain

INTRODUCTION Strong genetic associations have been found for a number of psychiatric disorders. However, understanding the underlying molecular mechanisms remains challenging. R...

The <tt>sva</tt> package for removing batch effects and other unwanted variation in high-throughput experiments

Abstract Summary: Heterogeneity and latent variables are now widely recognized as major sources of bias and variability in high-throughput experiments. The most well-known sourc...

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

Genes overlap across psychiatric disease Many genome-wide studies have examined genes associated with a range of neuropsychiatric disorders. However, the degree to which the gen...