Barney S. Graham

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

The mRNA-1273 vaccine induced anti-SARS-CoV-2 immune responses in all participants, and no trial-limiting safety concerns were identified. These findings support further develop...

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

The outbreak of a novel coronavirus (2019-nCoV) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycopr...

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

In this small study involving older adults, adverse events associated with the mRNA-1273 vaccine were mainly mild or moderate. The 100-μg dose induced higher binding- and neutra...

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

Vaccination of nonhuman primates with mRNA-1273 induced robust SARS-CoV-2 neutralizing activity, rapid protection in the upper and lower airways, and no pathologic changes in th...

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

Significance Coronaviruses such as Middle East respiratory syndrome coronavirus (MERS-CoV) cause severe respiratory distress with high fatality rates. The spike (S) glycoprotein...

Pre-fusion structure of a human coronavirus spike protein

Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies