C. David Allis

Translating the Histone Code

Chromatin, the physiological template of all eukaryotic genetic information, is subject to a diverse array of posttranslational modifications that largely impinge on histone ami...

The language of covalent histone modifications

Regulation of chromatin structure by site-specific histone H3 methyltransferases

Histone Acetyltransferases

▪ Abstract Transcriptional regulation in eukaryotes occurs within a chromatin setting and is strongly influenced by nucleosomal barriers imposed by histone proteins. Among the w...

Signaling to Chromatin through Histone Modifications

Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes

Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines

Conservation of deposition-related acetylation sites in newly synthesized histones H3 and H4.

Newly synthesized histone H4 is deposited in a diacetylated isoform in a wide variety of organisms. In Tetrahymena a specific pair of residues, lysines 4 and 11, have been shown...

Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide

Catalytic Mechanism and Function of Invariant Glutamic Acid 173 from the Histone Acetyltransferase GCN5 Transcriptional Coactivator

Within chromatin, reversible acetylation of core histones is critical for transcriptional activation of eukaryotic target genes. The recent identification of intrinsic histone a...

Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator

The yeast GCN5 (yGCN5) transcriptional coactivator functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Here, we present the high resolution cry...

Deposition-related histone acetylation in micronuclei of conjugating Tetrahymena.

Macro- and micronuclei of the ciliated protozoan, Tetrahymena thermophila, afford a unique opportunity to study histone acetylation under conditions where acetylation associated...

Signaling to Chromatin through Histone Modifications: How Clear Is the Signal?

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