David E. Hill

A Proteome-Scale Map of the Human Interactome Network

Two related regulatory sequences are required for maximal induction of Saccharomyces cerevisiae his3 transcription.

In Saccharomyces cerevisiae, the coordinate induction of his3 and other amino acid biosynthesis genes is mediated by the binding of GCN4 activator protein to specific promoter s...

A Map of the Interactome Network of the Metazoan <i>C. elegans</i>

To initiate studies on how protein-protein interaction (or “interactome”) networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elega...

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50–70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF(V...