Derek C. Angus

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

Sepsis is life-threatening organ dysfunction due to a dysregulated host response to infection. It is considered a major cause of health loss, but data for the global burden of s...

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19

In this prospective meta-analysis of clinical trials of critically ill patients with COVID-19, administration of systemic corticosteroids, compared with usual care or placebo, w...

Surviving Sepsis Campaign

To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008. A consensus committee of 68 internat...

Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

Severe sepsis is a common, expensive, and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction. It is especially common in the elde...

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

This document reflects a process whereby a group of experts and opinion leaders revisited the 1992 sepsis guidelines and found that apart from expanding the list of signs and sy...

The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis*

The Campaign was associated with sustained, continuous quality improvement in sepsis care. Although not necessarily cause and effect, a reduction in reported hospital mortality ...

Severe sepsis epidemiology: sampling, selection, and society.

Three new articles in Critical Care add to an expanding body of information on the epidemiology of severe sepsis. Although there have been a range of approaches to estimate the ...

E5 Murine Monoclonal Antiendotoxin Antibody in Gram-Negative Sepsis<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

Despite adequate sample size and high enrollment of patients with confirmed gram-negative sepsis, E5 did not improve short-term survival. Current study rationale and designs sho...