Douglas Hanahan

Hallmarks of Cancer: The Next Generation

The Hallmarks of Cancer

Cancer Cells Retrace a Stepwise Differentiation Program during Malignant Progression

Abstract Pancreatic neuroendocrine tumors (PanNET) comprise two molecular subtypes, relatively benign islet tumors (IT) and invasive, metastasis-like primary (MLP) tumors. Until...

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Mutationally corrupted cancer (stem) cells are the driving force of tumor development and progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly...

Induction of angiogenesis during the transition from hyperplasia to neoplasia

It is now well established that unrestricted growth of tumours is dependent upon angiogenesis. Previous studies on tumour growth, however, have not revealed when or how the tran...

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma

In a transgenic mouse model, dermal fibrosarcomas develop in a pathway comprised of at least three stages: mild fibromatosis, aggressive fibromatosis, and fibrosarcoma. The latt...