Gerald M. Rubin

Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor

Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation

The Drosophila Roughened mutation: Activation of a rap homolog disrupts eye development and interferes with cell determination

A Whole-Genome Assembly of <i>Drosophila</i>

We report on the quality of a whole-genome assembly of Drosophila melanogaster and the nature of the computer algorithms that accomplished it. Three independent external data so...

The Gene Ontology (GO) database and informatics resource

The Gene Ontology (GO) project (http://www. geneontology.org/) provides structured, controlled vocabularies and classifications that cover several domains of molecular and cellu...

Gene Ontology: tool for the unification of biology

Comparative Genomics of the Eukaryotes

A comparative analysis of the genomes of Drosophila melanogaster , Caenorhabditis elegans , and Saccharomyces cerevisiae —and the proteins they are predicted to encode—was under...

Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction

Recent studies suggest that the fly uses the inositol lipid signaling system for visual excitation and that the Drosophila transient receptor potential (trp) mutation disrupts t...

A Computer Program for Aligning a cDNA Sequence with a Genomic DNA Sequence

We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence ...

The Release 6 reference sequence of the <i>Drosophila melanogaster</i> genome

Drosophila melanogaster plays an important role in molecular, genetic, and genomic studies of heredity, development, metabolism, behavior, and human disease. The initial referen...