Hans Lehrach

Transcriptome and genome sequencing uncovers functional variation in humans

A global reference for human genetic variation

A complete BAC-based physical map of the Arabidopsis thaliana genome

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

Somatic Mutation Profiles of MSI and MSS Colorectal Cancer Identified by Whole Exome Next Generation Sequencing and Bioinformatics Analysis

We conclude that with deep sequencing of tumor exomes one may be able to predict the microsatellite status of CRC and in addition identify potentially clinically relevant mutati...

Defined physical limits of the Huntington disease gene candidate region.

The Huntington disease (HD) gene has been mapped 4 cM distal to D4S10 within the telomeric chromosome band, 4p16.3. The published physical map of this region extends from D4S10 ...

Radiation hybrid map spanning the huntington disease gene region of chromosome 4

The Huntington's disease candidate region exhibits many different haplotypes

Complex patterns of linkage disequilibrium in the Huntington disease region.

The genetic defect causing Huntington disease (HD) has been mapped to 4p16.3 by linkage analysis using DNA markers. Two apparently contradictory classes of recombination events ...

Cloning of the α–adducin gene from the Huntington's disease candidate region of chromosome 4 by exon amplification

A Global View of Gene Activity and Alternative Splicing by Deep Sequencing of the Human Transcriptome

The functional complexity of the human transcriptome is not yet fully elucidated. We report a high-throughput sequence of the human transcriptome from a human embryonic kidney a...

The ConsensusPathDB interaction database: 2013 update

Knowledge of the various interactions between molecules in the cell is crucial for understanding cellular processes in health and disease. Currently available interaction databa...

Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement

Researchers, supported by data from polyploid plants, have suggested that whole genome duplication (WGD) may induce genomic instability and rearrangement, an idea which could ha...