James R. Eshleman

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

This study showed that mismatch-repair status predicted clinical benefit of immune checkpoint blockade with pembrolizumab. (Funded by Johns Hopkins University and others; Clinic...

Somatic mutations in the chromatin remodeling gene <i>ARID1A</i> occur in several tumor types

Mutations in the chromatin remodeling gene ARID1A have recently been identified in the majority of ovarian clear cell carcinomas (OCCCs). To determine the prevalence of mutation...

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

There are currently few therapeutic options for patients with pancreatic cancer, and new insights into the pathogenesis of this lethal disease are urgently needed. Toward this e...

Distant metastasis occurs late during the genetic evolution of pancreatic cancer