Jeffrey I. Gordon

QIIME allows analysis of high-throughput community sequencing data

An obesity-associated gut microbiome with increased capacity for energy harvest

Human gut microbes associated with obesity

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

A translational medicine pipeline is described where human gut microbial communities and diets are re-created in gnotobiotic mice and the impact on microbe and host is defined u...

Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans

The normal range of physiological and metabolic phenotypes has been shaped by coevolution with microbial symbionts.

Predicting a Human Gut Microbiota’s Response to Diet in Gnotobiotic Mice

Model microbial communities in mouse guts respond quickly and predictably to dietary shifts.

Bacterial Community Variation in Human Body Habitats Across Space and Time

Growing on You The human gut and skin harbor diverse microbial communities that are known to vary strikingly among individuals. Here, Costello et al. (p. 1694 , published online...

Evolution of Mammals and Their Gut Microbes

Mammals are metagenomic in that they are composed of not only their own gene complements but also those of all of their associated microbes. To understand the coevolution of the...

Worlds within worlds: evolution of the vertebrate gut microbiota

Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins

We deeply sampled the organismal, genetic, and transcriptional diversity in fecal samples collected from a monozygotic (MZ) twin pair and compared the results to 1,095 communiti...

Evolution of Symbiotic Bacteria in the Distal Human Intestine

The adult human intestine contains trillions of bacteria, representing hundreds of species and thousands of subspecies. Little is known about the selective pressures that have s...

Direct sequencing of the human microbiome readily reveals community differences

Culture-independent studies of human microbiota by direct genomic sequencing reveal quite distinct differences among communities, indicating that improved sequencing capacity ca...

Ribosomal RNA diversity predicts genome diversity in gut bacteria and their relatives

The mammalian gut is an attractive model for exploring the general question of how habitat impacts the evolution of gene content. Therefore, we have characterized the relationsh...

The gut microbiota as an environmental factor that regulates fat storage

New therapeutic targets for noncognitive reductions in energy intake, absorption, or storage are crucial given the worldwide epidemic of obesity. The gut microbial community (mi...

Obesity alters gut microbial ecology

We have analyzed 5,088 bacterial 16S rRNA gene sequences from the distal intestinal (cecal) microbiota of genetically obese ob / ob mice, lean ob /+ and wild-type siblings, and ...

Metagenomic Analysis of the Human Distal Gut Microbiome

The human intestinal microbiota is composed of 10 13 to 10 14 microorganisms whose collective genome (“microbiome”) contains at least 100 times as many genes as our own genome. ...

Reciprocal Gut Microbiota Transplants from Zebrafish and Mice to Germ-free Recipients Reveal Host Habitat Selection

A core gut microbiome in obese and lean twins

The Human Microbiome Project

A strategy to understand the microbial components of the human genetic and metabolic landscape and how they contribute to normal physiology and predisposition to disease.

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

Commensal Host-Bacterial Relationships in the Gut

One potential outcome of the adaptive coevolution of humans and bacteria is the development of commensal relationships, where neither partner is harmed, or symbiotic relationshi...

Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells

The adult mouse intestine contains an intricate vascular network. The factors that control development of this network are poorly understood. Quantitative three-dimensional imag...

Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine

Human beings contain complex societies of indigenous microbes, yet little is known about how resident bacteria shape our physiology. We colonized germ-free mice with Bacteroides...

Getting a grip on things: how do communities of bacterial symbionts become established in our intestine?