John J.P. Kastelein

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Discovery and refinement of loci associated with lipid levels

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for c...

Common variants associated with plasma triglycerides and risk for coronary artery disease

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coro...

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent ...

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence...

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Very Low Levels of Atherogenic Lipoproteins and the Risk for Cardiovascular Events