Martin Vingron

Minimum information about a microarray experiment (MIAME)—toward standards for microarray data

Estimating Amino Acid Substitution Models: A Comparison of Dayhoff's Estimator, the Resolvent Approach and a Maximum Likelihood Method

Evolution of proteins is generally modeled as a Markov process acting on each site of the sequence. Replacement frequencies need to be estimated based on sequence alignments. He...

<i>Oases:</i>robust<i>de novo</i>RNA-seq assembly across the dynamic range of expression levels

Abstract Motivation: High-throughput sequencing has made the analysis of new model organisms more affordable. Although assembling a new genome can still be costly and difficult,...

A Global View of Gene Activity and Alternative Splicing by Deep Sequencing of the Human Transcriptome

The functional complexity of the human transcriptome is not yet fully elucidated. We report a high-throughput sequence of the human transcriptome from a human embryonic kidney a...

Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement

Researchers, supported by data from polyploid plants, have suggested that whole genome duplication (WGD) may induce genomic instability and rearrangement, an idea which could ha...