Tyler Jacks

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

MicroRNA expression profiles classify human cancers

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

Nuclear factor I/B is an oncogene in small cell lung cancer

Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characte...

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

p53 is required for radiation-induced apoptosis in mouse thymocytes

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

Apoptosis is a genetically encoded programme of cell death that can be activated under physiological conditions and may be an important safeguard against tumour development. Reg...