William C. Hahn

Next-generation characterization of the Cancer Cell Line Encyclopedia

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

Creation of human tumour cells with defined genetic elements

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

A number of genetic mutations have been identified in human breast cancers, yet the specific combinations of mutations required in concert to form breast carcinoma cells remain ...

Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling

A detailed understanding of the mechanisms by which tumors acquire resistance to targeted anticancer agents should speed the development of treatment strategies with lasting cli...

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50–70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF(V...