X. Shirley Liu

TIMER2.0 for analysis of tumor-infiltrating immune cells

Abstract Tumor progression and the efficacy of immunotherapy are strongly influenced by the composition and abundance of immune cells in the tumor microenvironment. Due to the l...

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Cancer treatment by immune checkpoint blockade (ICB) can bring long-lasting clinical benefits, but only a fraction of patients respond to treatment. To predict ICB response, we ...

Landscape of tumor-infiltrating T cell repertoire of human cancers

ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia

Chromatin immunoprecipitation (ChIP) followed by high-throughput DNA sequencing (ChIP-seq) has become a valuable and widely used approach for mapping the genomic location of tra...

Model-based Analysis of ChIP-Seq (MACS)