Ze’ev A. Ronai

Role of redox potential and reactive oxygen species in stress signaling

Conformation-dependent phosphorylation of p53

Phosphorylation of the p53 tumor suppressor protein is known to modulate its functions. Using bacterially produced glutathione S -transferase (GST)-p53 fusion protein and baculo...

A Role for ATF2 in Regulating MITF and Melanoma Development

The transcription factor ATF2 has been shown to attenuate melanoma susceptibility to apoptosis and to promote its ability to form tumors in xenograft models. To directly assess ...

A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis

Melanoma is one of the most lethal cutaneous malignancies, characterized by chemoresistance and a striking propensity to metastasize. The transcription factor ATF2 elicits oncog...