Brunel University of London

GENCODE reference annotation for the human and mouse genomes

The accurate identification and description of the genes in the human and mouse genomes is a fundamental requirement for high quality analysis of data informing both genome biol...

Characterising and justifying sample size sufficiency in interview-based studies: systematic analysis of qualitative health research over a 15-year period

Widespread Sexual Disruption in Wild Fish

A number of chemicals present in the environment have been shown to mimic or antagonize the actions of steroid hormones, an issue often described as "endocrine disruption/modula...

Estrogenic Effects of Effluents from Sewage Treatment Works

Abstract The occurrence of hermaphrodite fish in the lagoons of sewage treatment works led us to hypothesize that sewage effluent might contain a substance, or substances, estro...

Identification of Estrogenic Chemicals in STW Effluent. 2. In Vivo Responses in Trout and Roach

The occurrence of certain natural and synthetic steroidal estrogens in the final effluent from STW has been demonstrated. 17β-Estradiol and estrone were present at concentration...

Reproductive Effects of Long-Term Exposure to Bisphenol A in the Fathead Minnow (<i>Pimephales promelas</i>)

Bisphenol A (BPA), a high-volume chemical used to make polycarbonate plastic, epoxy resins, and other chemicals has been reported to be weakly estrogenic. To investigate the eff...

Assessing the Biological Potency of Binary Mixtures of Environmental Estrogens using Vitellogenin Induction in Juvenile Rainbow Trout (<i>Oncorhynchus mykiss</i>)

Experiments were conducted to assess the in vivo potency of binary mixtures of estrogenic chemicals using plasma vitellogenin (VTG) concentrations in juvenile rainbow trout (Onc...

Nonylphenol Affects Gonadotropin Levels in the Pituitary Gland and Plasma of Female Rainbow Trout

Female rainbow trout (Oncorhynchus mykiss) were exposed to 4-nonylphenol (NP) at (mean measured) concentrations of 0.7, 8.3, and 85.6 micrograms/L for 18 weeks, during early ova...

Intermittent Exposure of Fish to Estradiol

The majority of testing for the effects of chemicals on fish has, historically, been designed to provide continuous exposure to constant concentrations. However, in the environm...