Canada's Michael Smith Genome Sciences Centre

Signatures of mutational processes in human cancer

Integrative analysis of 111 reference human epigenomes

The Immune Landscape of Cancer

We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identi...

The repertoire of mutational signatures in human cancer

Comparative Genomics of the Eukaryotes

A comparative analysis of the genomes of Drosophila melanogaster , Caenorhabditis elegans , and Saccharomyces cerevisiae —and the proteins they are predicted to encode—was under...

De novo assembly and analysis of RNA-seq data

Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical Applications

In-depth characterization of the microRNA transcriptome in a leukemia progression model

MicroRNAs (miRNAs) have been shown to play important roles in physiological as well as multiple malignant processes, including acute myeloid leukemia (AML). In an effort to gain...

An Interactive Analysis and Exploration Tool for Epigenomic Data

Abstract In this design study, we present an analysis and abstraction of the data and tasks related to the domain of epigenomics, and the design and implementation of an interac...