Cancer Research Institute

Mutations of the BRAF gene in human cancer

The tumor microenvironment

Paradoxical roles of the immune system during cancer development

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

Vascular endothelial growth factor (VEGF) is an apparently endothelial cell-specific mitogen that is structurally related to platelet-derived growth factor. By Northern blot and...

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

When the mammalian proto-oncogene bcl-2 is overexpressed it can protect various types of cells both from normal and from experimentally induced apoptosis, but the molecular mech...

Distinct molecular mechanism for initiating TRAF6 signalling

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.

Cellular Plasticity in Cancer

Abstract During cancer progression, tumor cells undergo molecular and phenotypic changes collectively referred to as cellular plasticity. Such changes result from microenvironme...