Erasmus Hospital

The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure

Surviving Sepsis Campaign

To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008. A consensus committee of 68 internat...

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Treatment with drotrecogin alfa activated significantly reduces mortality in patients with severe sepsis and may be associated with an increased risk of bleeding.

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

GLIM criteria for the diagnosis of malnutrition – A consensus report from the global clinical nutrition community

Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

The genetics underlying severe COVID-19 The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that...

Separation of samples into their constituents using gene expression data

Abstract Gene expression measurements are a powerful tool in molecular biology, but when applied to heterogeneous samples containing more than one cellular type the results are ...

Validation of diagnostic magnetic resonance imaging criteria for multiple sclerosis and response to interferon β1a

Abstract In the recently proposed diagnostic criteria for multiple sclerosis (MS) by McDonald, the modified magnetic resonance imaging (MRI) Barkhof criteria have been incorpora...