Fondazione IRCCS Istituto Nazionale dei Tumori

Sorafenib in Advanced Hepatocellular Carcinoma

In patients with advanced hepatocellular carcinoma, median survival and the time to radiologic progression were nearly 3 months longer for patients treated with sorafenib than f...

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer

Among patients with advanced, previously treated squamous-cell NSCLC, overall survival, response rate, and progression-free survival were significantly better with nivolumab tha...

Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer

In patients with previously untreated metastatic nonsquamous NSCLC without EGFR or ALK mutations, the addition of pembrolizumab to standard chemotherapy of pemetrexed and a plat...

BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update

Computed Tomography Screening and Lung Cancer Outcomes

Screening for lung cancer with low-dose CT may increase the rate of lung cancer diagnosis and treatment, but may not meaningfully reduce the risk of advanced lung cancer or deat...

Local Recurrences Following Mastectomy: Support for the Concept of Tumor Dormancy

This study provides evidence that the hypothesis of uninterrupted constant growth of locally recurring breast tumors should be rejected, as it implies a statistically significan...

Pulmonary Nodules: Volume Repeatability at Multidetector CT Lung Cancer Screening

Semiautomatic volumetry is sufficiently accurate and repeatable and may be useful in assisting with lung nodule management in a lung cancer screening program.

Inhibition of RET tyrosine kinase by SU5416

Thyroid neoplasia is frequently associated with rearranged during transfection (RET) proto-oncogene mutations that cause hyperactivation of RET kinase activity. Selective inhibi...

Results of a breast-cancer-surgery trial compared with observational data from routine practice