Frederick National Laboratory for Cancer Research

Remdesivir for the Treatment of Covid-19 — Final Report

Our data show that remdesivir was superior to placebo in shortening the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory trac...

DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)

Abstract DAVID is a popular bioinformatics resource system including a web server and web service for functional annotation and enrichment analyses of gene lists. It consists of...

Functional profiling of the Saccharomyces cerevisiae genome

Determining the effect of gene deletion is a fundamental approach to understanding gene function. Conventional genetic screens exhibit biases, and genes contributing to a phenot...

Comparative Genomics of the Eukaryotes

A comparative analysis of the genomes of Drosophila melanogaster , Caenorhabditis elegans , and Saccharomyces cerevisiae —and the proteins they are predicted to encode—was under...

Metastasis Results from Preexisting Variant Cells Within a Malignant Tumor

Clones derived in vitro from a parent culture of murine malignant melanoma cells varied greatly in their ability to produce metastatic colonies in the lungs upon intravenous ino...

APOBEC3B is an enzymatic source of mutation in breast cancer

Methods for High-Density Admixture Mapping of Disease Genes

Evidence for the Clonal Origin of Spontaneous Metastases

A cultured cell line of the K-1735 melanoma was x-irradiated to induce chromosome breakage and rearrangements and then was implanted into the footpads of syngenic C3H mice. Spon...

Chromosomal Inheritance of Epigenetic States in Fission Yeast During Mitosis and Meiosis

KSR: a MAPK scaffold of the Ras pathway?

ABSTRACT Kinase Suppressor of Ras (KSR) is an intriguing component of the Ras pathway that was first identified by genetic studies performed in Drosophila melanogaster and Caeno...