German Primate Center

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health emergency. Cell entry...

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

ABSTRACT The spike (S) protein of the severe acute respiratory syndrome coronavirus (SARS-CoV) can be proteolytically activated by cathepsins B and L upon viral uptake into targ...

The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells

Abstract The emergence of a novel, highly pathogenic coronavirus, 2019-nCoV, in China, and its rapid national and international spread pose a global health emergency. Coronaviru...

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

Corticotropin‐releasing factor receptor type 1 from <i>Tupaia belangeri</i>

A cDNA clone encoding corticotropin‐releasing factor (CRF) type 1 (CRF‐R1) has been isolated from the tree shrew Tupaia belangeri with a PCR‐based approach. The full‐length cDNA...