Harefield Hospital

Global Unmet Needs in Cardiac Surgery

More than 6 billion people live outside industrialized countries and have insufficient access to cardiac surgery. Given the recently confirmed high prevailing mortality for rheu...

Evaluating drug targets through human loss-of-function genetic variation

The effect of LRRK2 loss-of-function variants in humans

Abstract Human genetic variants predicted to cause loss-of-function of protein-coding genes (pLoF variants) provide natural in vivo models of human gene inactivation and can be ...

Multiple parameter cross‐species protein identification using MultiIdent ‐ a world‐wide web accessible tool

Abstract Recent increases in the number of genome sequencing projects means that the amount of protein sequence in databases is increasing at an astonishing pace. In proteome st...