Helmholtz Centre for Infection Research

Natural products in drug discovery: advances and opportunities

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug target a...

Matlnd and Matlnspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

The identification of potential regulatory motifs in new sequence data is increasingly important for experimental design. Those motifs are commonly located by matches to IUPAC s...

Molecular biology of cellulose production in bacteria

Microglia provide neuroprotection after ischemia

ABSTRACT Many neurological insults are accompanied by a marked acute inflammatory reaction, involving the activation of microglia. Using a model of exogenous application of fluo...

Impact of biofilm matrix components on interaction of commensal Escherichia coli with the gastrointestinal cell line HT-29