Hope Center for Neurological Disorders

Toward discovery science of human brain function

Although it is being successfully implemented for exploration of the genome, discovery science has eluded the functional neuroimaging community. The core challenge remains the d...

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

Abstract During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker resear...

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ ₄₂ in humans

Abstract Objectives Amyloid‐β 42 (Aβ 42 ) appears central to Alzheimer's disease (AD) pathogenesis and is a major component of amyloid plaques. Mean cerebrospinal fluid (CSF) Aβ...

The pulvinar and visual salience

Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease

Patients with Alzheimer's disease vary in their ability to sustain cognitive abilities in the presence of brain pathology. A major open question is which brain mechanisms may su...

Left striato-pallidal hyperactivity in schizophrenia. Part II: Phenomenology and thought disorder.

Our previous paper summarized abundant evidence that schizophrenic patients show forms of sensory and motor hemineglect compatible with a left striato-pallidal hyperactivity mod...

Epilepsy is both a symptom and a disease: A proposal for a two-tiered classification system

I appreciate the opportunity to add my opinion to the discussion of the complex subject of epilepsy classification, as prompted by the recent International League Against Epilep...