Hospices Civils de Lyon

ILAE Official Report: A practical clinical definition of epilepsy

Summary Epilepsy was defined conceptually in 2005 as a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. This definition is usual...

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

In this international study of CAR T-cell therapy in relapsed or refractory diffuse large B-cell lymphoma in adults, high rates of durable responses were produced with the use o...

DNA methylation-based classification of central nervous system tumours

MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis

The use of risk assessment with MRI before biopsy and MRI-targeted biopsy was superior to standard transrectal ultrasonography-guided biopsy in men at clinical risk for prostate...

Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias

Recent work provides direct empirical evidence for the existence of study publication bias and outcome reporting bias. There is strong evidence of an association between signifi...

Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial

Treatment of hypertension in patients 80 years and older: the lower the better? A meta-analysis of randomized controlled trials

Treating hypertension in very old patients reduces stroke and heart failure with no effect on total mortality. The most reasonable strategy is the one associated with significan...

Exercise with incorporated expiratory manoeuvres was as effective as breathing techniques for airway clearance in children with cystic fibrosis: a randomised crossover trial

A session of various whole-body exercises interspersed with independent expiratory manoeuvres could be an acceptable substitute for a session of breathing control, thoracic expa...