Max Planck Institute for Metabolism Research

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma

Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics, and targeted therapeutics. Systematic efforts to a...

Modeling Genomic Diversity and Tumor Dependency in Malignant Melanoma

Abstract The classification of human tumors based on molecular criteria offers tremendous clinical potential; however, discerning critical and “druggable” effectors on a large s...

Predicting drug susceptibility of non–small cell lung cancers based on genetic lesions

Somatic genetic alterations in cancers have been linked with response to targeted therapeutics by creation of specific dependency on activated oncogenic signaling pathways. Howe...

Fine mapping of the association with obesity at the FTO locus in African-derived populations

Genome-wide association studies have identified many common genetic variants that are associated with polygenic traits, and have typically been performed with individuals of rec...