Michigan Medicine

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

Oncogenic Signaling Pathways in The Cancer Genome Atlas

A reference panel of 64,976 haplotypes for genotype imputation

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI): A Completed Reference Database of Lung Nodules on CT Scans

Purpose: The development of computer‐aided diagnostic (CAD) methods for lung nodule detection, classification, and quantitative assessment can be facilitated through a well‐char...

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021

INTRODUCTION Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection (1). Sepsis and septic shock are major healthcare problems, impacti...

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits

The obesity epidemic is responsible for a substantial economic burden in developed countries and is a major risk factor for type 2 diabetes and cardiovascular disease. The disea...

Large-scale association analysis identifies new risk loci for coronary artery disease

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching geno...

Molecular Mechanisms and Clinical Pathophysiology of Maturity-Onset Diabetes of the Young

Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of disorders characterized by nonketotic diabetes mellitus, an autosomal dominant mode of inherit...