Molecular Oncology (United States)

Hallmarks of Cancer: The Next Generation

The basics of epithelial-mesenchymal transition

The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly understoo...

The biology of VEGF and its receptors

<i>MGMT</i> Gene Silencing and Benefit from Temozolomide in Glioblastoma

Patients with glioblastoma containing a methylated MGMT promoter benefited from temozolomide, whereas those who did not have a methylated MGMT promoter did not have such a benefit.

The repertoire of mutational signatures in human cancer

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

The proto-oncogenes c- fos and c- jun function cooperatively as inducible transcription factors in signal transduction processes. Their protein products, Fos and Jun, form a het...

VEGF and the quest for tumour angiogenesis factors

Structure of the Epidermal Growth Factor Receptor Kinase Domain Alone and in Complex with a 4-Anilinoquinazoline Inhibitor

The crystal structure of the kinase domain from the epidermal growth factor receptor (EGFRK) including forty amino acids from the carboxyl-terminal tail has been determined to 2...

Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells

We examined the role of vascular endothelial growth factor (VEGF) in preventing apoptosis in primary human umbilical vein endothelial (HUVE) cells. VEGF was capable of preventin...

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

Expression of BAX, without another death stimulus, proved sufficient to induce a common pathway of apoptosis. This included the activation of interleukin 1β-converting enzyme (I...