National Institute of Mental Health

The Epidemiology of Major Depressive Disorder

Major depressive disorder is a common disorder, widely distributed in the population, and usually associated with substantial symptom severity and role impairment. While the rec...

Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used upt...

On Methods in the Analysis of Profile Data

This paper is concerned with methods for analyzing quantitative, non-categorical profile data, e.g., a battery of tests given to individuals in one or more groups. It is assumed...

Toward discovery science of human brain function

Although it is being successfully implemented for exploration of the genome, discovery science has eluded the functional neuroimaging community. The core challenge remains the d...

On Face-Work

Serotonin Transporter Genetic Variation and the Response of the Human Amygdala

A functional polymorphism in the promoter region of the human serotonin transporter gene ( SLC6A4 ) has been associated with several dimensions of neuroticism and psychopatholog...

Complementary DNA Sequencing: Expressed Sequence Tags and Human Genome Project

Automated partial DNA sequencing was conducted on more than 600 randomly selected human brain complementary DNA (cDNA) clones to generate expressed sequence tags (ESTs). ESTs ha...

‘What’ and ‘where’ in the human brain

Open Mass Spectrometry Search Algorithm

Large numbers of MS/MS peptide spectra generated in proteomics experiments require efficient, sensitive and specific algorithms for peptide identification. In the Open Mass Spec...

Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI