Osaka City University

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

Dilated cardiomyopathy is a severe pathology of the heart with poorly understood etiology. Disruption of the gene encoding the negative immunoregulatory receptor PD-1 in BALB/c ...

Subcellular Localization of Toll-Like Receptor 3 in Human Dendritic Cells

Abstract Toll-like receptor (TLR)3 recognizes dsRNA and transduces signals to activate NF-κB and IFN-β promoter. Type I IFNs (IFN-α/β) function as key cytokines in anti-viral ho...

A Complete Terrestrial Radiocarbon Record for 11.2 to 52.8 kyr B.P.

Dating Carbon Radiocarbon dating is the best way to determine the age of samples that contain carbon and that are younger than ∼50,000 years, the limit of precision for the meth...

Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: results of the West Japan Thoracic Oncology Group trial (WJTOG0403)

The purpose of this study was to evaluate the efficacy of gefitinib and the feasibility of screening for epidermal growth factor receptor (EGFR) mutations among select patients ...

Prognostic value of microsatellite instability in resectable pancreatic cancer.

The significance of microsatellite instability (MSI) as a prognostic predictor for resectable pancreatic cancer patients was examined. Forty-six histologically confirmed pancrea...

SG06, a fully continuous and varved sediment core from Lake Suigetsu, Japan: stratigraphy and potential for improving the radiocarbon calibration model and understanding of late Quaternary climate changes

A novel approach to varve counting using μXRF and X-radiography in combination with thin-section microscopy, applied to the Late Glacial chronology from Lake Suigetsu, Japan