Pacific Biosciences (United States)

A second generation human haplotype map of over 3.1 million SNPs

Haplotype-resolved de novo assembly using phased assembly graphs with hifiasm

Nonhybrid, finished microbial genome assemblies from long-read SMRT sequencing data

Real-Time DNA Sequencing from Single Polymerase Molecules

We present single-molecule, real-time sequencing data obtained from a DNA polymerase performing uninterrupted template-directed synthesis using four distinguishable fluorescentl...

Phased diploid genome assembly with single-molecule real-time sequencing

Mapping single molecule sequencing reads using basic local alignment with successive refinement (BLASR): application and theory

The results indicate that it is possible to map SMS reads with high accuracy and speed. Furthermore, the inferences made on the mapability of SMS reads using our combinatorial m...

Assembling large genomes with single-molecule sequencing and locality-sensitive hashing

Long-read sequence assembly of the gorilla genome

Improving on the gorilla genome Access to complete, high-quality genomes of nonhuman primates will also help us understand human biology. Gordon et al. used long-read sequencing...

ALLPATHS 2: small genomes assembled accurately and with high continuity from short paired reads

Liver and Adipose Expression Associated SNPs Are Enriched for Association to Type 2 Diabetes

Genome-wide association studies (GWAS) have demonstrated the ability to identify the strongest causal common variants in complex human diseases. However, to date, the massive da...