Torrey Pines Institute For Molecular Studies

The Protein Kinase Complement of the Human Genome

We have catalogued the protein kinase complement of the human genome (the “kinome”) using public and proprietary genomic, complementary DNA, and expressed sequence tag (EST) seq...

The Genome Sequence of <i>Drosophila melanogaster</i>

The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular...

Large-scale analysis of the yeast proteome by multidimensional protein identification technology

Oncogenic kinase signalling

Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction pathways mediating development and multicellular communication in metazoans. Their ...

Evolution of protein kinase signaling from yeast to man

Protein phosphorylation controls many cellular processes, especially those involved in intercellular communication and coordination of complex functions. To explore the evolutio...