University of Minnesota Medical Center

Standards of Medical Care in Diabetes

I write in reference to the recently updated and circulated “Standards of Medical Care in Diabetes,” in particular part II, “Screening for Diabetes,” which were recently updated...

The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure

Carvedilol reduces the risk or death as well as the risk of hospitalization for cardiovascular causes in patients with heart failure who are receiving treatment with digoxin, di...

Structure, Function, and Evolution of Coronavirus Spike Proteins

The coronavirus spike protein is a multifunctional molecular machine that mediates coronavirus entry into host cells. It first binds to a receptor on the host cell surface throu...

RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory

Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of patients with neurodegenerative diseases and have been implicated in mediating neuron...

Abnormal Centrosome Amplification in the Absence of p53

The centrosome plays a vital role in mitotic fidelity, ensuring establishment of bipolar spindles and balanced chromosome segregation. Centrosome duplication occurs only once du...

Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)

Here, we describe the generation of a novel transgenic mouse model of human tauopathy. The rTg(tau P301L )4510 mouse expresses the P301L mutation in tau (4R0N) associated with f...

Practical approach to determining costs and frequency of adverse drug events in a health care network

The frequency, preventability, severity, root causes, and projected costs of adverse drug events (ADEs) occurring after or causing admission to a four-hospital integrated academ...

Lifetime Risk of Atrial Fibrillation by Race and Socioeconomic Status

Background: Limited information exists on the lifetime risk of atrial fibrillation (AF) in African Americans and by socioeconomic status. Methods: We studied 15 343 participants...

American Heart Association's Life's Simple 7: Avoiding Heart Failure and Preserving Cardiac Structure and Function