Abstract
Production of skeletal muscle hypoplasia by 3-acetylpyridine and its complete reversal by nicotinamide in developing chicken embryos have been confirmed. Cultures of developing embryonic chicken muscle show degenerative effects produced by 3-acetylpyridine; these effects are reversed by nicotinamide. Cartilage production in cultured chondrogenic cells is potentiated by 3-acetylpyridine; this potentiation is completely reversed by nicotinamide. It is suggested that nicotinamide- or pyridine-nucleotide-dependent reactions influence normal differentiation of limb mesoderm cells by inhibiting chondrogenic-cell and potentiating muscle-cell expression or proliferation.
Keywords
NicotinamideChondrogenesisEmbryoIn vitroMesodermCartilageSkeletal muscleChemistryCell biologyEmbryonic stem cellBiologyEndocrinologyInternal medicineBiochemistryAnatomyMedicine
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Publication Info
- Year
- 1968
- Type
- article
- Volume
- 160
- Issue
- 3831
- Pages
- 1009-1010
- Citations
- 62
- Access
- Closed
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Cite This
Arnold I. Caplan,
Edgar Zwilling,
Nathan O. Kaplan
(1968).
3-Acetylpyridine: Effects in vitro Related to Teratogenic Activity in Chicken Embryos.
Science
, 160
(3831)
, 1009-1010.
https://doi.org/10.1126/science.160.3831.1009
Identifiers
- DOI
- 10.1126/science.160.3831.1009