Abstract

If I only had a heart 3D bioprinting is still a fairly new technique that has been limited in terms of resolution and by the materials that can be printed. Lee et al. describe a 3D printing technique to build complex collagen scaffolds for engineering biological tissues (see the Perspective by Dasgupta and Black). Collagen gelation was controlled by modulation of pH and could provide up to 10-micrometer resolution on printing. Cells could be embedded in the collagen or pores could be introduced into the scaffold via embedding of gelatin spheres. The authors demonstrated successful 3D printing of five components of the human heart spanning capillary to full-organ scale, which they validated for tissue and organ function. Science , this issue p. 482 ; see also p. 446

Keywords

Human heartComputer scienceMedicineCardiology

MeSH Terms

BioprintingCollagenExtracellular MatrixHeart VentriclesHumansHydrogelsHydrogen-Ion ConcentrationMicrovesselsModelsAnatomicMyocytesCardiacNeovascularizationPhysiologicPrintingThree-DimensionalX-Ray Microtomography

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Publication Info

Year
2019
Type
article
Volume
365
Issue
6452
Pages
482-487
Citations
1655
Access
Closed

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Cite This

Andrew Lee, Andrew R. Hudson, Daniel J. Shiwarski et al. (2019). 3D bioprinting of collagen to rebuild components of the human heart. Science , 365 (6452) , 482-487. https://doi.org/10.1126/science.aav9051

Identifiers

DOI
10.1126/science.aav9051
PMID
31371612

Data Quality

Data completeness: 90%