Abstract

A relatively high percentage (ca. 15%) of aqueous extracts from terrestrial plants, cyanobacteria, and marine invertebrates and algae has exhibited activity in the National Cancer Institute's primary AIDS-antiviral screen. By removal of anionic polysaccharides in a first stage of dereplication, we have eliminated from further consideration a considerable number of these extracts. However, a still substantial proportion of the active extracts remained, from which we wished to select and prioritize a small percentage for our detailed bioassay-directed fractionation studies. Therefore, a chemical screening protocol, utilizing various solid-phase extraction cartridges, has been developed for a second-stage dereplication and to assist in prioritization of these extracts for our further investigations.

Keywords

CitationPrioritizationHuman immunodeficiency virus (HIV)Computer scienceOrder (exchange)Library scienceInformation retrievalMedicineImmunologyEngineering

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Year
1993
Type
article
Volume
56
Issue
7
Pages
1123-1129
Citations
98
Access
Closed

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John H. Cardellina, Murray H. G. Munro, Richard W. Fuller et al. (1993). A Chemical Screening Strategy for the Dereplication and Prioritization of HIV-Inhibitory Aqueous Natural Products Extracts. Journal of Natural Products , 56 (7) , 1123-1129. https://doi.org/10.1021/np50097a016

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DOI
10.1021/np50097a016