Abstract

Steroids may rapidly alter neuronal function and behavior through poorly characterized, direct actions on neuronal membranes. The membrane-bound receptors mediating these behavioral responses have not been identified. [ 3 H]Corticosterone labels a population of specific, high-affinity recognition sites (dissociation constant = 0.51 nanomolar) in synaptic membranes from an amphibian brain. These binding sites were localized by receptor autoradiography in the neuropil, outside the regions of perikarya. The affinities of corticoids for this [ 3 H]corticosterone binding site were linearly related to their potencies in rapidly suppressing male reproductive behavior. Thus, it appears that brain membranes contain a corticosteroid receptor that could participate in the regulation of behavior.

Keywords

ReceptorMembraneNeuropilCorticosteroneDissociation constantBiologyAmphibianPopulationAffinitiesBinding siteSynaptic membraneEndocrinologyNeuroscienceBiophysicsInternal medicineCell biologyChemistryBiochemistryCentral nervous systemMedicineEcologyHormone

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Publication Info

Year
1991
Type
article
Volume
252
Issue
5014
Pages
1848-1851
Citations
519
Access
Closed

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Miles Orchinik, Thomas F. Murray, Frank L. Moore (1991). A corticosteroid Receptor in Neuronal Membranes. Science , 252 (5014) , 1848-1851. https://doi.org/10.1126/science.2063198

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DOI
10.1126/science.2063198