Abstract
Several tissue culture cell lines that were transformed by a tumor virus have been found to react with an agglutinin, while under identical conditions their untransformed parent cell lines did not agglutinate. Since a short treatment of the parent cell line with low concentrations of proteases exposed the same agglutinin receptor sites in a fashion indistinguishable from the transformed cells, it is proposed that both viral and chemical transformation produce changes in the architecture of the membrane, identical to those of the proteases.
Keywords
ProteasesCell cultureAgglutininCellTransformation (genetics)BiologyReceptorCell biologyMembraneCell surface receptorCell membraneMolecular biologyVirologyChemistryBiochemistryLectinEnzymeGeneticsGene
MeSH Terms
AnimalsAntibodiesBinding SitesCell LineCell TransformationNeoplasticChick EmbryoCricetinaeCulture TechniquesElectrophoresisDiscFibroblastsKidneyLectinsLiverMembranesMethodsNeoplasmsExperimentalOncogenic VirusesPeptide HydrolasesRatsSimian virus 40
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Publication Info
- Year
- 1969
- Type
- article
- Volume
- 62
- Issue
- 3
- Pages
- 994-1001
- Citations
- 547
- Access
- Closed
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Cite This
Max M. Burger
(1969).
A DIFFERENCE IN THE ARCHITECTURE OF THE SURFACE MEMBRANE OF NORMAL AND VIRALLY TRANSFORMED CELLS.
Proceedings of the National Academy of Sciences
, 62
(3)
, 994-1001.
https://doi.org/10.1073/pnas.62.3.994
Identifiers
- DOI
- 10.1073/pnas.62.3.994
- PMID
- 4308100
- PMCID
- PMC223697