Abstract

The investigation of the three-dimensional structure of the DNA aptamer d(G1G2T3-T4G5G6T7G8T9G10G11T12T13G14G15) which binds to and inhibits thrombin has been carried out by NMR methods. This DNA exhibits a number of long-range NOEs between residues which are not adjacent in sequence, which allowed the determination of the novel tertiary structure adopted. This DNA adopts a highly compact, highly symmetrical structure which consists of two tetrads of guanosine base pairs and three loops. The residues of the tetrads alternate anti-syn-anti-syn. This novel structural motif for DNA may also be relevant to the structure of telomere DNA.

Keywords

AptamerCitationSocial mediaIconComputer scienceAltmetricsDNAInformation retrievalComputational biologyWorld Wide WebChemistryMolecular biologyBiologyBiochemistry

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Publication Info

Year
1993
Type
article
Volume
32
Issue
8
Pages
1899-1904
Citations
331
Access
Closed

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Ke Yu Wang, Sarah N. McCurdy, Regan G. Shea et al. (1993). A DNA aptamer which binds to and inhibits thrombin exhibits a new structural motif for DNA. Biochemistry , 32 (8) , 1899-1904. https://doi.org/10.1021/bi00059a003

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DOI
10.1021/bi00059a003