Abstract

A series of automated instruments that use state-of-the-art chemical methods has been developed for high-sensitivity protein sequencing, DNA synthesis and peptide synthesis. These instruments have been integrated into a centralized microchemical facility in order to promote their use for the study of a variety of biologically interesting problems. This facility has as one of its major functions the development of new chemistries and instrumentation for the structural analysis and synthesis of genes and proteins.

Keywords

Computational biologyChemistryComputer scienceBiology

MeSH Terms

Amino Acid SequenceAntibodiesAutoanalysisBase SequenceChromatographyHigh Pressure LiquidComputersGenesGenesSyntheticIndicators and ReagentsMass SpectrometryOligodeoxyribonucleotidesPhenylthiohydantoinProteins

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Publication Info

Year
1984
Type
article
Volume
310
Issue
5973
Pages
105-111
Citations
136
Access
Closed

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Cite This

Michael W. Hunkapiller, Stephen B. H. Kent, Marvin H. Caruthers et al. (1984). A microchemical facility for the analysis and synthesis of genes and proteins. Nature , 310 (5973) , 105-111. https://doi.org/10.1038/310105a0

Identifiers

DOI
10.1038/310105a0
PMID
6738709

Data Quality

Data completeness: 81%