A Nonpeptidyl Growth Hormone Secretagogue

Abstract

A nonpeptidyl secretagogue for growth hormone of the structure 3-amino-3-methyl- N -(2,3,4,5-tetrahydro-2-oxo-1-{[2′-(1 H -tetrazol-5-yl) (1,1′-biphenyl)-4-yl]methyl}-1 H -1-benzazepin-3( R )-yl)-butanamide (L-692,429) has been identified. L-692,429 synergizes with the natural growth hormone secretagogue growth hormone-releasing hormone and acts through an alternative signal transduction pathway. The mechanism of action of L-692,429 and studies with peptidyl and nonpeptidyl antagonists suggest that this molecule is a mimic of the growth hormone-releasing hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH 2 (GHRP-6). L-692,429 is an example of a nonpeptidyl specific secretagogue for growth hormone.

Keywords

SecretagogueHormoneChemistryEndocrinologyGrowth-hormone-releasing hormone receptorInternal medicineGrowth hormoneStereochemistryBiologyBiochemistryReceptorHormone receptorMedicine

Affiliated Institutions

Merck & Co., Inc., Rahway, NJ, USA (United States) US

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Publication Info

Year: 1993
Type: article
Volume: 260
Issue: 5114
Pages: 1640-1643
Citations: 348
Access: Closed

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APA Style

                            
                                
                                    Roy G. Smith, 
                                
                                    Kang Cheng, 
                                
                                    William R. Schoen
                                
                                et al.
                            
                            (1993). 
                            A Nonpeptidyl Growth Hormone Secretagogue. 
                            Science
                            , 260
                            (5114)
                            , 1640-1643.
                            https://doi.org/10.1126/science.8503009
                        

Identifiers

DOI: 10.1126/science.8503009