Abstract

Neutrophils and allergen-specific T cells accumulate in patients with allergic late-phase reactions (LPRs). Their presence is associated with severe inflammation. Cytokines, such as GM-CSF, IFN-γ, and IL-3, which are typically found in patients with allergic LPRs, have been proposed to convert neutrophils into antigen-presenting cells (APCs). We sought to assess the antigen-processing and antigen-presenting capacities of neutrophils from allergic patients. Neutrophils can serve as APCs for local allergen-specific effector T cells in patients with allergic LPRs.

Keywords

ImmunologyAllergyImmunoglobulin EPresentation (obstetrics)MedicineAntigenAntigen presentationAntibodyImmune systemT cell

MeSH Terms

AllergensAntigen PresentationBetulaCytokinesHumansHypersensitivityImmunoglobulin ENeutrophilsPollenRhinitisAllergicSeasonalT-Lymphocytes

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Publication Info

Year
2018
Type
article
Volume
143
Issue
3
Pages
1143-1152.e4
Citations
66
Access
Closed

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Cite This

Dominika Polak, Christine Häfner, Peter Briza et al. (2018). A novel role for neutrophils in IgE-mediated allergy: Evidence for antigen presentation in late-phase reactions. Journal of Allergy and Clinical Immunology , 143 (3) , 1143-1152.e4. https://doi.org/10.1016/j.jaci.2018.06.005

Identifiers

DOI
10.1016/j.jaci.2018.06.005
PMID
29920351
PMCID
PMC6986898

Data Quality

Data completeness: 86%