A Preliminary Study on Shortening the Postoperative Immobilization Time after Femoral Artery Puncture in the Chinese Population

Abstract

<title>Abstract</title> Objective According to the Chinese "Clinical Practice Guidelines for Transarterial Chemoembolization of Liver Cancer" (Version 2021), the operative limb should be immobilized for 6–12 hours following femoral arterial puncture. In 2001, the American Heart Association and its Committee on Clinical Cardiology recommended immobilizing the surgical limb for 2–6 hours. Prolonged immobilization might create discomfort, defer treatment plans, and reduce bed utilization. It is worth investigating whether the Chinese population's postoperative immobilization period might be reduced. The purpose of this study was to determine the feasibility of shortening the postoperative immobilization time following femoral artery puncture. Methods Hemostasis, compression, bandaging, and immobility following femoral artery puncture are all linked to postoperative problems. We chose the best current hemostasis approach while keeping consistent compression and bandaging circumstances. Furthermore, we investigated the possibility of reducing postoperative immobilization time. To ensure adequate hemostasis at the puncture site, we used an in vitro hemostasis test to find a hemostatic patch with greater efficiency. On this basis, we investigated the prospect of shortening the immobilization period following femoral artery puncture. We enrolled 82 individuals who agreed to a 5F femoral artery puncture from six hospitals in China. Accoring to the Central Randomization principle, patients were randomly assigned to one of the two groups: early mobilization (immobilization time: 5 ~ 6 hours) or late mobilization (8 ~ 12 hours). The rates of complications, such as postoperative puncture site hemorrhage and subcutaneous hematoma, were compared between them. Results In the hemostasis effect test assay, the chitin hemostatic patch shows a better hemostatic effect than gauze and was thus chosen as the fixed condition for the hemostatic stages in subsequent investigations. The complication ratio after femoral artery puncture did not differ significantly between individuals randomly assigned to early or late mobilization (P = 0.999, 95% CI: -2.6%~11.8%). Early mobilization is safe for individuals undergoing 5F femoral artery puncture in included Chinese population. Conclusion Immobilization time shortening after femoral artery puncture in the Chinese population is potential which requires additional validation in a larger sample. This reduced immobilization time will serve to relieve patient discomfort, shorten the course of disease, and promote the development of outpatient interventional treatment.

Affiliated Institutions

• Shanghai Tenth People's Hospital CN
• Weifang People's Hospital CN
• The Fourth People's Hospital of Zibo City CN
• Tongji University CN
• Second Hospital of Shandong University CN
• Tianjin Medical University Cancer Institute and Hospital CN

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