A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

Abstract

Both MAb114 and REGN-EB3 were superior to ZMapp in reducing mortality from EVD. Scientifically and ethically sound clinical research can be conducted during disease outbreaks and can help inform the outbreak response. (Funded by the National Institute of Allergy and Infectious Diseases and others; PALM ClinicalTrials.gov number, NCT03719586.).

Keywords

Ebola virusRandomized controlled trialContext (archaeology)MedicineDiseaseIntensive care medicineVirologyInternal medicineBiology

MeSH Terms

Adenosine MonophosphateAdolescentAdultAlanineAntibodiesMonoclonalAntiviral AgentsChildChildPreschoolDemocratic Republic of the CongoDisease OutbreaksEbolavirusFemaleHemorrhagic FeverEbolaHumansInfantInfantNewbornInfusionsIntravenousMaleRNAViralRibonucleotidesSingle-Blind MethodYoung Adult

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Publication Info

Year: 2019
Type: article
Volume: 381
Issue: 24
Pages: 2293-2303
Citations: 1557
Access: Closed

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APA Style

                            
                                
                                    Sabué Mulangu, 
                                
                                    Lori E. Dodd, 
                                
                                    Richard T. Davey
                                
                                et al.
                            
                            (2019). 
                            A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics. 
                            New England Journal of Medicine
                            , 381
                            (24)
                            , 2293-2303.
                            https://doi.org/10.1056/nejmoa1910993
                        

Identifiers

DOI: 10.1056/nejmoa1910993
PMID: 31774950
PMCID: PMC10680050

Data Quality

Data completeness: 90%