A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

Abstract

Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.

Keywords

HypothalamusEndocrinologyInternal medicineReceptorG protein-coupled receptorPituitary glandBiologyHormoneHeterotrimeric G proteinG proteinChemistryMedicine

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Publication Info

Year: 1996
Type: article
Volume: 273
Issue: 5277
Pages: 974-977
Citations: 2059
Access: Closed

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APA Style

                            
                                
                                    Andrew D. Howard, 
                                
                                    Scott D. Feighner, 
                                
                                    Doris Cully
                                
                                et al.
                            
                            (1996). 
                            A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release. 
                            Science
                            , 273
                            (5277)
                            , 974-977.
                            https://doi.org/10.1126/science.273.5277.974
                        

Identifiers

DOI: 10.1126/science.273.5277.974