A recombination event that redefines the Huntington disease region.

Abstract

We report both a recombination event that places the Huntington disease gene proximal to the marker D4S98 and an extended linkage-disequilibrium study that uses this marker and confirms the existence of disequilibrium between it and the HD locus. We also report the cloning of other sequences in the region around D4S98, including a new polymorphic marker R10 and conserved sequences that identify a gene in the region of interest.

Keywords

Linkage disequilibriumGeneticsBiologyLocus (genetics)RecombinationHuntington's diseaseGenetic markerDisequilibriumGeneHaplotypeAlleleCloning (programming)Disease

Affiliated Institutions

University of Wales GB

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Publication Info

Year: 1992
Type: article
Volume: 51
Issue: 2
Pages: 357-62
Citations: 19
Access: Closed

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APA Style

                            
                                    Russell G. Snell, 
                                
                                    Leslie M. Thompson, 
                                
                                    Dan Tagle
                                
                                et al.
                            
                            (1992). 
                            A recombination event that redefines the Huntington disease region.. 
                            PubMed
                            , 51
                            (2)
                            , 357-62.