Abstract

The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. In the forthcoming decade, a much greater share of new nitrogen-based pharmaceuticals is anticipated. Many new nitrogen-based heterocycles have been designed. The number of novel N-heterocyclic moieties with significant physiological properties and promising applications in medicinal chemistry is ever-growing. In this review, we consolidate the recent advances on novel nitrogen-containing heterocycles and their distinct biological activities, reported over the past one year (2019 to early 2020). This review highlights the trends in the use of nitrogen-based moieties in drug design and the development of different potent and competent candidates against various diseases.

Keywords

NitrogenDrug discoveryChemistryCombinatorial chemistryNanotechnologyOrganic chemistryMaterials scienceBiochemistry

MeSH Terms

Drug DesignDrug DevelopmentHeterocyclic CompoundsHumansMolecular StructureNitrogenStructure-Activity Relationship

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Publication Info

Year
2020
Type
review
Volume
25
Issue
8
Pages
1909-1909
Citations
1472
Access
Closed

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Cite This

Nagaraju Kerru, Lalitha Gummidi, Suresh Maddila et al. (2020). A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications. Molecules , 25 (8) , 1909-1909. https://doi.org/10.3390/molecules25081909

Identifiers

DOI
10.3390/molecules25081909
PMID
32326131
PMCID
PMC7221918

Data Quality

Data completeness: 86%